With global climate change and rapid urbanization process, rainstorm flood disaster has become major issues and severe challenges faced by human society and economic development. Vulnerability assessment is important basic content of risk assessment, which is a hot point researchof international disaster prevention and mitigation. The authors utilizeda revised SCS model to calculate heavy rain runoff by DEM and the depth of flood inundation for different return periods. Based on six returnperiods o f 20, 50, 100, 200, 500 and 1000 years, we select Pudong NewArea as case study and apply GIS and remote sensing technology to carry out hazards analysis and vulnerability analysis in th is paper. Base on the grid, we reclassify and draw up the inundation depth maps for different return periods. The data on disaster loss rate of mainstorm inundation in study area was survived and the vulnerability classification for study area was carried out. The obtained results give a reference to assessment of regional disaster and planning of disaster prevention and reduction.